Make This Your Homepage   •   Bookmark Us   •   Download our Toolbar  
India Education Diary : Eden of Education
HomeAdmissionEdu PolicyScholarshipExamNotificationsCompetitionsExam ResultsEdu Jobs
SEARCH

International study finds 21 genes tied to cholesterol levels
Friday, October 12, 2012
  Related News
Aligarh Muslim University is organizing 14th IIRS Outreach Programme on Application of Remote Sensing, GIS
Tuesday, January 20, 2015
Aligarh: The Department of Geology, Aligarh Muslim University is organizing 14th IIRS Outreach Programme on Application of Remote Sensing and GIS for Natural Resources for teachers, research scholars and postgraduate students from 27th January to 27th March, in collaboration with Indian Institute of Remote Sensing, Indian Space Research Organization.
State Level Inter-School Science Exhibition by Rajalakshmi Institutions
Sunday, January 18, 2015
New Delhi: The Chennai based Rajalakshmi Group of Educational Institutions, who have pioneered higher education in the last 17 years, are once again organizing the popular inter-school Science Exhibition on 23rd and 24th  January from 09:00 am to 3:00pm.
Ismat Literacy and Handicraft Centre of the AMU Ladies' Club paid tribute to late Dr. Jamila Majid Siddiqui
Sunday, January 18, 2015
Aligarh: The Ismat Literacy and Handicraft Centre of the AMU Ladies" Club today paid a rich tribute to late Dr.
Community Service Program at TRIO World School
Friday, January 16, 2015
Bangalore: As part of Community Service Program & the ongoing Swachh Bharat Abhiyan, students of TRIO World School has made eco friendly dustbins, where garbage can be easily separated.
Vice-Chancellor, JMI inaugurates 2015 with academic visits
Sunday, January 11, 2015
New Delhi: Prof.


London: In a UCL-led study, published in the American Journal of Human Genetics, an international consortium of over 180 scientists report the identification of 21 new gene variants associated with cholesterol predictors of heart disease and metabolic disorders.

The findings expand the list of potential targets for drugs and other treatments for lipid-related cardiovascular disease, a leading global cause of death and disability.

The International IBC Lipid Genetics Consortium analysed genetic data from over 90,000 individuals of European ancestry, covering approximately 50,000 DNA markers across 2,000 genes implicated in cardiovascular disease.

This study identified 21 novel genes associated with levels of low-density lipoproteins (LDL, or “bad cholesterol”), high-density lipoproteins (HDL, “good cholesterol”), total cholesterol (TC), and triglycerides (TG), as well as verifying 49 previously known signals. The researchers also found that some of the strongest signals appeared to have gender-specific effects and a more complex genetic architecture than previously thought.

Dr Fotios Drenos, UCL Institute of Cardiovascular Science, and Dr Brendan Keating of The Children’s Hospital of Philadelphia, are senior authors of the current study.

Dr Drenos said: “While each of the genetic variants has a small effect on the specific lipid trait, their cumulative effect can significantly add up to put people at risk for disease.
“This study underscores how international sharing of resources and datasets paves the way for robust, continuing discoveries of new and unexpected information from human genetic studies.”

Dr Keating added: “To date, this is one of the largest number of DNA samples ever used in a study for lipid traits, it clearly shows the value of using broad-ranging global scientific collaborations to yield new gene signals.”

Drs Drenos and Keating coordinated efforts among four main data collecting sites: the Center for Applied Genomics at The Children’s Hospital of Philadelphia; the UCL Institute of Cardiovascular Science; AMC, Amsterdam; and the Department of Cardiology at the University Medical Center, Utrecht.

The consortium is following this published work with a project to identify which of the loci reported directly cause disease, and how this knowledge can help in the development of novel drugs. The consortium will also devote its significant pooled resources to identifying interactions among genetic polymorphisms and biological markers of downstream cardiovascular disease.

Lead author Folkert Asselbergs, M.D., Ph.D., of University Medical Center, Utrecht, added: “Next to already established drug targets such as the LDL receptor and PCSK9, the current study identified 21 potential new targets for drug development that may be beneficial for the treatment of dyslipidaemia in the future. Our team of researchers are now initiating additional studies to investigate the impact of the found genes on cardiovascular disease.”

More than 30 organizations and agencies funded this study, including the British Heart Foundation, the Medical Research Council, the National Institutes of Health and the Wellcome Trust.
 
Email Story   Feedback   Print Story

 
Admission Notifications
GET LATEST ADMISSION NOTIFICATION
PGDM 2015 Admission at ISB&M
IIHMR University, Jaipur invites applications for MBA in Health Economics, Finance and Ins urance Management
RSV Combined Shiksha B.Ed./M.Ed Entrance
Ph.D at Raman Research Institute
Integrated Ph. D progs at Kashmir University
MBA 2015 admission at NIT, Trichy
ASCI's PGDHM Admissions Open

 
Exam/Test Alert
GET LATEST EXAM/TEST ALERT
SBVU PG Ent. Test 2015
Bridge Program at NIFT: Apply by Oct 10
IUCAA-NCRA Admission Test (INAT-2014)
Combined Med Services Exam 2014
DNB PDCET July 2014: Exam on June 18
PGDRDM at NIRD: Entrance Test on June 1
Combined Defence Services Examination (I) 2014 on February 9


Advertisement

  Press Release
Xanax effects
Resort casino


 
Type of studies Edu Bodies Career Options/counseling Exam result/alert Others
  Medical
  Engineering
  Computer
  Law
  Humanities
  Statutory Bodies
  IIMs
IITs IITs
  Universities
  Boarding school
  Career Options
  Career Counselling
  Coaching
  Interview tips
  Resume Making
  Scholarship
  Exam result
  Exam Alert
  Admission
  Notifications
  Top colleges
  Top universities
  Kids Corner
  Schools
  Tender
IndiaEducationDiary Search

India Education Diary | Admission | Edu Tender | Scholarship | Exam | Notifications | Competitions | Exam Results | Edu Jobs
| About Us | Mission | Advertise with us | Contact Us | Feed Back |
2006-07 All rights reserved worldwide by www.indiaeducationdiary.com
India Education Diary